Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance
Fig 5
Effects of [L28K]esculentin-2CHa on plasma glucose and insulin concentrations following intraperitoneal (A–D) and oral (E-H) glucose administration (18 mmol/kg body weight) in lean and high-fat fed mice as well as insulin sensitivity (I, J).
Insulin sensitivity tests were performed using 25 U/kg body weight of insulin injected intraperitoneally. All tests were conducted following twice-daily treatment of mice with saline or [L28K]esculentin-2CHa (75 nmol/kg body weight) for 28 days. Values are mean ± SEM with n = 8 mice. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with saline-treated lean mice. ΔP < 0.05, ΔΔP < 0.01 compared with high-fat fed control.