Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity
Fig 5
Agonist and silent agonist activity of muscarinic cholinergic agonists.
The pharmacophore for silent agonism of α7 is distinct from that for activation in the absence of a PAM [25]. Since arecoline is known to be a muscarinic agonist, we tested additional compounds with muscarinic activity for their ability to activate α7 in the absence and presence of 10 μM PNU-120596. The structures of the test compounds are shown, as well as, that of nicotine for comparison.