Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding
Fig 3
Chromatographic profiles of the PNA monomer derivatives (diastereomers).
(A) Mixture of diastereomers 7a and 7b; (B) Diastereomer 7a (Conditions: Luna column, 5 μm, CN 100A, elution system: heptane/isopropanol (88/12), flow rate: 1 mL/min); (C) Mixture of diastereomers 8a and 8b; (D) Diastereomer 8a (Conditions: Separon SGX RP-S C18 column, 5 μm, 4x150 mm, elution system: acetonitrile/water (1/1), flow rate: 1 mL/min); R = -CH2CH2COOBn.