Calcium Ion Flow Permeates Cells through SOCs to Promote Cathode-Directed Galvanotaxis
Fig 6
The PI3K Pathway Was Involved in Galvanotaxis.
Treatment with the RTK inhibitor AG1478 (10 μM), the PI3K inhibitor LY294002 (30 μM), the actin polymerization inhibitor CB (1 μg/ml) or the myosin-inhibitor BB (25 μM) abolished cathode-oriented cell migration, but treatment with Y27632 (10 μM) or U0126 (10 μM) did not. * (p < 0.05) and ** (p < 0.01) vs EF 5 V/cm control. Error bars indicate standard error.