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Stereochemical Control in the Still-Wittig Rearrangement Synthesis of Cyclohexyl (Z)-Alkene Inhibitors of Pin1

Fig 6

Determination of the stereochemistry of of (2S,5S)-14.

The 2D NOESY spectrum is shown with lettering of the major conformation showing key nOe interactions. Crosspeaks between Hi and Hh, and between He and Hi’ show the stereochemistry given.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0139543.g006