TMPyP4, a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase Inhibitor
Fig 2
In vitro vs. in vivo modulation of Th expression by TMPyP4.
A, transcription assays with SH-SY5Y cells transfected with a reporter under the control of the rat 4.5kb Th promoter that are also treated with either saline, TMPyP2 or TMPyP4. Mean relative promoter activities are shown with error bars representing the standard deviation. ** indicates p<0.001, * indicates p = 0.02 and n.s. indicates not significant. B, Th transcript levels, as measured by quantitative RT-PCR, in the adrenal glands, olfactory bulb and midbrain of adult mice administered either saline, TMPyP2 or TMPyP4 (n = 8 for both male and female). Mean relative transcript levels are shown with error bars representing the standard error of the mean. ** indicates p<0.01, * indicates p = 0.03 and n.s. indicates not significant.