Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis
Fig 6
Biosynthesis, remodeling, and transport of GPI-APs in mammalian cells.
GPI is biosynthesized in the ER from PI by the stepwise addition of sugars, an acyl-chain and phospho-ethanolamines. After GPI is transferred to a protein, GPI moieties are remodeled during transport. Genes colored in blue (italic) have been shown to decrease surface expression of GPI-APs in mutant cells. Genes significantly enriched and genes weakly enriched in this study are highlighted in yellow and light yellow, respectively.