Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion
Fig 1
Histological characterization of the gastric mucosa of WT and ClC-2-/- mice.
A. Haematoxylin and eosin staining of the gastric mucosa of WT and ClC-2-/- mice is shown. Flat pink cells with purple nuclei are parietal cells; dark purple cells are zymogen cells (arrowheads). Brackets indicate the gastric gland layer and * indicates places of glandular dilation. Bar = 50 μm. B. Height of the gastric gland region was measured in WT and ClC-2-/- mice. Results are plotted as mean ± SE (n = 6). *P<0.001 versus WT. C. PAS-AB staining of mucus cells in WT and ClC-2-/- mouse gastric mucosa. Neutral mucin positive surface mucus cells are dark pink and parietal cells show faint pink staining. Bar = 25 μm.