Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design
Fig 5
Post-hoc fits in representative ferrets.
Observed and simulated OC PK in representative ferrets from studies 1 and 2: (A) rich PK in an H5N1-inoculated ferret administered a 12.5 mg/kg OP dose; (B) rich PK in an uninfected ferret administered a 5.0 mg/kg OP dose; (C) sparse PK in an H5N1-infected ferret administered 25.0 mg/kg OP q12h; (D) sparse PK in an H3N2-infected ferret administered 12.5 mg/kg OP every twelve h (q12h); (E) PK for an uninfected ferret in the PK control group administered 0.76, 3.8, and 19.0 mg/kg OP on days 1, 3, and 5, respectively; and (F) sparse PK in a ferret inoculated with influenza B/Yamagata/16/1988 influenza virus administered 3.8 mg/kg OP q12h.