Exploring Strong Interactions in Proteins with Quantum Chemistry and Examples of Their Applications in Drug Design
Fig 2
The salt-bridge interaction structures between three amino acid cations (Arg+ Lys+, and His+) and three acidic amino acids (Asp-, Glu-, and His).
A) The salt-bridge structure of Lys+–Asp-. B) The salt-bridge structure of Lys+–Glu-. C) The salt-bridge structure of Lys+–His. D) The salt-bridge structure of Arg+–Asp-. E) The salt-bridge structure of Arg+–Glu-. F) The salt-bridge structure of Arg+–His. G) The salt-bridge structure of His+–Asp-. H) The salt-bridge structure of His+–Gln-. I) The salt-bridge structure of His+–His. The energies of aa salt bridge interactions are in the range -90 to -520 kJ/mol.