Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study
Fig 5
Noncontact specular microscopy images of corneal endothelium before and after ripasudil administration in non-instilled eye.
In 3 of 6 typical healthy subjects, before administration (Top row), 1.5 hours after the initial administration on day 0 (Second row), 6 hours after the initial administration on day 0 (Third row), and before the final administration on day 7 (Bottom row) of ripasudil in non-instilled eye, in subject 1 (Left column), subject 2 (Middle column), and subject 5 (Right column). Throughout the observation period, there were no morphological changes of corneal endothelial cells in non-instilled eye.