Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice
Fig 5
Guanosine metabolism is affected by both aging and A53T mutation.
(A) Scatter plot depicts the alteration of guanosine levels in different age and genotype groups. One-way ANOVA test, **q value <0.01; ***q value <0.001. (B) Line graph highlights the age-dependent changes of guanosine in A53T and nTg mice. One-way ANOVA test, ***q value <0.001. (C) Schematic diagram summarizes the alanine metabolic (in yellow shade) and acetyl-CoA biosynthesis (in blue shade) pathways mainly affected by aging, and the purine metabolic (in pink shade) pathway influenced by both aging and genotypes. The metabolites highlighted with the bold font represent the ones differentially altered between groups (q value < 0.05 in two-way ANOVA test).