Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
Fig 4
M084 treatment reverses the CUS-induced pathological behaviors.
(A) M084 (10 mg/kg, 2 hrs) and amitriptyline (10 mg/kg, 7 days) treatment decreased immobility time in the FST of CUS-exposed mice. (B) In novelty suppressed feeding test (NSFT), CUS increased the latency to feed, while M084 treatment reversed such an effect. (C-E) In locomotor activity test, mice subjected CUS displayed moderate changes over the average speed (C), distance traveled in central area and the total distance traveled (D), and time in central area (E). M084 treatment had no effect on these changes induced by CUS. Results are showed as mean ± SEM. N = 12/group, * p < 0.05, ** p < 0.01, *** p < 0.001.