Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
Fig 1
M084 exhibits antidepressant-like effects in mice.
(A) The chemical structure of M084. (B&C) M084 reduced immobility time in forced swim test (FST, B) and tail suspension test (TST, C). Amitriptyline, a known antidepressant, was used as a positive control (10 mg/kg, 2 hrs). (D-F) In locomotor activity test, mice treated with vehicle and M084 (10 mg/kg, 2 hrs) showed no difference over the average speed (D), distance in central area and total distance traveled (E), and time in central area (F). Results are presented as mean ± SEM. N = 10–12/group, * p < 0.05, ** p < 0.01.