The Food Contaminant Mycotoxin Deoxynivalenol Inhibits the Swallowing Reflex in Anaesthetized Rats
Fig 5
DON (570ng/kg bw; 10 trials) microinjection within the central pattern generator of swallowing (SwCPG) inhibited rhythmic swallowing triggered by SLN stimulation.
A. Electromyogram from sublingual muscles (note the rhythmic swallowing induced by SLN stimulation). DON microinjection at 570ng/kg bw induced a rapid and powerful inhibition of the number of swallows. 30 seconds after DON application, no more swallow was triggered by SLN stimulation. This effect was transient since the swallows recovered after 45 minutes. B. Electrocardiogram and respiratory activity recorded during 30 seconds (before, during and after SLN stimulation). Note the blockade of respiration induced by swallowing during SLN stimulation in control condition and at recovery 45 min after DON injection.