Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2
Fig 5
NOP receptor / G protein interaction experiments—concentration-response curves to N/OFQ in absence and in presence of increasing concentrations (1–100 nM) of SB-612111 (left panel).
The corresponding Schild plot is shown in the middle panel. The inhibition response curve to SB-612111 vs. N/OFQ 30 nM is shown in the right panel. Data are mean ± sem of 4 separate experiments performed in duplicate.