Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties
Fig 13
In vivo anti-tumor efficacy of compound 4g (N = 6).
(a) 4g effectively inhibited the growth of A375 xenograft tumor after three weeks continuous treatment (i.p. injection) in a dose-dependent manner (left panel) without causing obvious decrease of mice body weight (right panel). (b) Western blotting results on the A375 xenograft tumor tissues (each lane represents one single mice). (c) Representative images of TUNEL assay using the formalin-fixed tumor sections.