Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties
Fig 12
Representative drug affinity responsive target stability (DARTS) results for pronase-digested A375 or M14 cell lysates.
Immunoblotting showed protection of the target protein, survivin, by incubation with compound 4g at the concentration of 20 μM, whereas digestion of the non-target proteins like GAPDH was unchanged.