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Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties

Fig 5

Synthesis of compounds 10a-10b.

Reagents and conditions: (a) 2-phenylethanol for 9a, 3-phenyl-1-propanol for 9b, 110 ^oC; (b) NH₄OH, H₂O, Et₂O, pH 8–10; (c) paraformaldehyde, pyrrolidine, EtOH, reflux.

doi: https://doi.org/10.1371/journal.pone.0129807.g005