< Back to Article

Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties

Fig 4

Synthesis of compounds 8a-8b.

Reagents and conditions: (a) benzyl alcohol, 110 ^oC; (b) NH₄OH, H₂O, Et₂O, pH 8–10; (c) paraformaldehyde, piperidine for 8a, morpholine for 8b,EtOH, reflux.

doi: https://doi.org/10.1371/journal.pone.0129807.g004