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Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties

Fig 3

Synthesis of compounds 6a-6g.

Reagents and conditions: (a) R²CH₂OH, NaH, THF, reflux; (b) R²CH₂OH, 110 ^oC; (c) NH₄OH, H₂O, Et₂O, pH 8–10; (d) paraformaldehyde, pyrrolidine,EtOH, reflux.

doi: https://doi.org/10.1371/journal.pone.0129807.g003