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Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K

Fig 4

BPLE and TCA inhibit UVB-induced Akt phosphorylation but not Mitogen-activated kinase (MAPK) signaling pathway in HaCaT cells.

A-D, Cells were treated with BPLE (A, C) and TCA (B, D) at the indicated concentration for 1 h before exposed to 0.01 J/cm2 of UVB and collected after 30 min. Phosphorylated and total protein levels were analyzed by Western blot assay. Relative band intensity is expressed as fold of control and indicated on top of each band.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0128365.g004