Slow Breathing and Hypoxic Challenge: Cardiorespiratory Consequences and Their Central Neural Substrates
Fig 5
Focal brainstem activity correlating with physiological changes.
Selected illustration of activity correlated with physiological changes. Data is illustrated at a voxel-wise threshold significance of P<0.001 uncorrected). A) within medulla, where the same locus reflects blood pressure increases and heart rate variability increases consistent with a neural substrate for the baroreflex mediating adjustments to hypoxic challenge. B) within pons and midbrain, where adjacent nuclei demonstrate relationships with decreases in heart rate and increases in tidal volume, putatively representing human homologues of brainstem centres supporting cardiorespiratory coupling as identified in experimental animals.