Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases
Fig 5
Effects of proton pump inhibitors on pancreatic secretion rates in rats.
Controls are represented as blue line and in each graph n is 6, 4, 7 and 4 respectively. A: Effects of 5 mg/kg (red line, n = 4) and 20 mg/kg omeprazole (green line, n = 6) on non-fasted rats. B: Effects of 5 mg/kg (red line, n = 4) and 20 mg/kg omeprazole (green line, n = 4) on fasted rats. C: Effect of 10 mg/kg SCH28080 (yellow line, n = 6) on fasted rats. D: Effects of long term (30 days) daily administration of 5 mg/kg omeprazole (red line, n = 4). Secretory rates are represented as mean values ± SEM. * indicates P<0.05, ** P<0.01.