The Repellent DEET Potentiates Carbamate Effects via Insect Muscarinic Receptor Interactions: An Alternative Strategy to Control Insect Vector-Borne Diseases
Fig 5
Orthosteric and allosteric binding sites of mammal M1 and M3 muscarinic receptors.
In all panels, the M1 and M3 mAChRs orthosteric and allosteric binding sites are shown with the ligand DEET in green. Residues observed in vicinity of DEET in M1 mAChR orthosteric site (A) and allosteric region (B) and in M3 mAChR orthosteric site (C) and allosteric site (D) are shown in licorice representations. The following colour coding for transmembrane helices used: TM1—orange, TM2—green, TM3—dark blue, TM4—yellow, TM5—red, TM6—magenta, TM7—light blue.