Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance
Fig 5
Analytical sensitivity of SMB and DLP probes on mutant DNA from clinical samples.
Success rates for the detection of selected mutants by the SMB and the DLP assays are shown. Panel (A) rpoB mutants; panel (B) gyrA mutants and panel (C) rrs/eis mutants. Solid lines show SMB assay performance and dotted lines show DLP assay performance.