Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration
Fig 6
Summarized working models of affecting Gal3-pCav1 function.
Extracellular Gal3 and non-caveolar pCav1 each stabilizes FAK within FAs dependent on each other. Expression of PTRF disrupts this function through three possible ways: 1) by recruiting pCav1 away from non-caveolar Cav1 scaffolds and into caveolae; 2) by direct interaction with non-caveolar pCav1; 3) by affecting Gal3 secretion and thus extracellular Gal3 concentration. Through which pathway PTRF affects Gal3-pCav1 function on FA dynamics remains to be studied.