STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells
Fig 6
SLN-STAT3 decoy ODN complexes inhibit migration and invasion of ovarian cancer cells.
(A) SLN-decoy ODN exhibited slower wound recovery at 24 and 48 hours after wounding compared with the NC and scrambled ODN groups. (B) A transwell invasion assay showed that SLN-decoy ODN inhibited cell invasion. At 48 hours after transfection, cells were reseeded to the upper transwell chamber for 24 hours and stained with crystal violet. (C) Western blot analysis showed that SLN-decoy ODN increased E-cadherin expression and reduced Snail and MMP9 expression. The data are expressed as the means ± SD of three independent experiments, * P < 0.05, ** P < 0.01 compared with NC.