STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells
Fig 5
SLN-STAT3 decoy ODN complexes induce autophagy of ovarian cancer cells.
(A) Transmission electron micrographs showing autophagic vesicles (AVs; white arrows) after transfection with the SLN-STAT3 decoy ODN in A2780 (a) and SKOV3 (b) cells. (c) Double-membrane AVs. (d) AVs containing cytosolic components. (B) Acridine orange staining at 48 hours after treatment in each group. (D) Western blot analysis showed that SLN-STAT3 decoy ODN reduced the expression of p-Akt, p-mTOR and increased the expression of LC3A-II, LC3B-II and Beclin-1.