STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells
Fig 4
SLN-STAT3 decoy ODN complexes induce apoptosis of ovarian cancer cells.
(A) SLN-decoy ODN induced a significant increase in apoptosis in SKOV3 and A2780 cells. After 48 hours of transfection, cell apoptosis was detected by annexin V-FITC/PI double-staining assay with flow cytometry. (B) Western blot assays showed that SLN-decoy ODN led to distinct up-regulation of Bax and cleaved caspase 3 and down-regulation of Bcl-2, pro-caspase 3 and Survivin. The data are expressed as the means ± SD of three independent experiments, ** P < 0.01 compared with NC.