STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells
Fig 2
Cell viability of ODN formulations by MTT assay.
SKOV3 (A) and A2780 (B) cells were treated with negative agents (negative control, NC), SLN-decoy ODN complexes, SLN-scrambled ODN complexes, naked ODN, Lipofectamine 2000-decoy ODN complexes (Lipo-decoy ODN), SLN and Lipofectamine 2000 at different concentrations (12.5, 25 and 50 nmol/L). At 48 hours after treatment, an MTT assay was performed. SKOV3 (C) and A2780 (D) cells were transfected with serial concentrations of SLN-decoy ODN complexes (12.5, 25 and 50 nmol/L), and cell viability was assessed at 24, 48 and 72 hours. The data are expressed as the means ± SD of three independent experiments, * P < 0.05, ** P < 0.01 compared with NC.