Cystamine Preparations Exhibit Anticoagulant Activity
Fig 4
Cystamine inhibits the amidolytic activity of coagulation enzymes.
Factors IXa (circles), Xa (squares), VIIa (diamonds), XIa (triangles), and thrombin (inverted triangles) amidolytic activity were assayed by incubating enzymes with cystamine (A) or T101 (B) and measuring the cleavage rate of chromogenic substrates. The data show means of 2–3 experiments per enzyme.