Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor
Fig 4
In vivo ARG of [14C]TAK-063 in rats.
The chemical structure of [14C]TAK-063 (A). The asterisk denotes the labeled position. Autoradiograms of head sections were obtained from male rats 6 h after single oral administration of [14C]TAK-063. The autoradiograms of 40 μm sagittal sections between 2.1 to 2.4 mm lateral to midline were taken (B). The locations for each coronal section relative to the bregma were 1.7 to 1.2 mm (C), 0.48 to −0.26 mm (D), −0.4 to −0.8 mm (E), −2.8 to −3.1 mm (F), −6.0 to −6.3 mm (G), and −12.7 to −12.8 mm (H). Acc, nucleus accumbens; Cb, cerebellum; Cpu, caudate putamen; Ctx, cortex; Fcx, frontal cortex; GP, globus pallidus; Hipp, hippocampus; MO, medulla oblongata; OT, olfactory tubercle; SN, substantia nigra; Thal, thalamus; VP, ventral pallidum.