Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor
Fig 2
In vitro autoradiography (ARG) using [3H]TAK-063 in mouse brain sections.
[3H]TAK-063 selectively accumulated in the caudate putamen (CPu; black arrow) and nucleus accumbens (NAc; white arrow) of wild-type (WT) mouse brain sections (A). The selective accumulation of [3H]TAK-063 in these areas did not occur in Pde10a-KO mouse brain sections (B). Radioactivity levels in the CPu of brain sections in the presence and absence of an excess amount of MP-10 are represented as a percent of total binding of WT mice (C). Data are represented as mean ± SEM.