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Thinprep plus Papanicolaou Stain Method Is More Sensitive than Cytospin-Coupled Wright Giems Stain Method in Cerebrospinal Fluid Cytology for Diagnosis of Leptomeningeal Metastasis from Solid Tumors

Fig 2

Side-by-side comparisons of CSF cytology results between the Thinprep plus Papanicolaou stain method (a, c, e, g, i and k) and the Cytospin-WG method (b, d, f, h, j and l) in patients with LM from various solid tumors.

Representative slides from identical CSF samples are shown for the same samples using the two methods in paired photos: a and b, gastric adenocarcinoma origin; c-h, lung adenocarcinoma origin; i and j breast adenocarcinoma origin; k and l, small-cell lung cancer origin. m-p, the typical features of malignancy of tumor cells seen by the Cytospin- WG stain method.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0122016.g002