MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4
Fig 5
Nickel and cobalt activate MyD88-dependent and -independent pathways.
HEK293/hTLR4 cells were transfected with luciferase reporter plasmids (constitutive Renilla-luciferase reporter and inducible) (A) IFNβ-responsive or (B) IP-10-responsive firefly-luciferase reporter) and with plasmid encoding wild type hMD-2. *p<0,01; **p<0,001; (t-test, compared to the unstimulated control). The chart legend applies to both panels.