Magnolol Administration in Normotensive Young Spontaneously Hypertensive Rats Postpones the Development of Hypertension: Role of Increased PPAR Gamma, Reduced TRB3 and Resultant Alleviative Vascular Insulin Resistance
Fig 5
PPARγ inhibition decreased effects of MAG incubation on PPARγ expression and insulin-stimulated signaling pathway in human umbilical vein endothelial cells.
Representative western blots showing PPARγ (A), TRB3 (B), phosphorylated Akt / Akt (C), and phosphorylated eNOS / eNOS (D), and NO release (E) in the conditioned medium. HG/HF, high glucose/high fat treatment; Mag, magnolol. All values are presented as mean ± SEM. n = 5–6. *P<0.05 vs. Control, #P<0.05 vs. HG/HF, $P<0.05 vs. HG/HF+Scrmbled siRNA.