Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells
Fig 2
Th17 cells are not a major subset of T helper cells in BXD2 mice.
(A) Flow cytometry analysis of the percentage and number of IFN-γ or IL-17A positive CD4+ T cells in the spleen from WT and BXD2 mice at the age of 6 months or older. (B) IL-17A levels in the sera of WT and BXD2 mice at the age of 6 months or older were measured by ELISA. (C) Quantitative RT-PCR analysis of Th1 or Th17 cell related genes from WT and BXD2 mice splenocytes at the age of 6 months or older. Data are representative of the analysis (A~C) indicate mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared with BXD2-WT mice.