Optomotor-Blind Negatively Regulates Drosophila Eye Development by Blocking Jak/STAT Signaling
Fig 6
Functional relationship between wg and omb.
(A) dpp>arm+GFP eye discs were reduced in size and showed no neuronal differentiation (Wg, red; Elav, cyan; GFP, Green). (B, D) dpp>arm+omb-RNAi caused partial rescue of eye disc size and neuronal differentiation (B) and adult eye (D). (C, E) dpp>omb-RNAi+GFP did not affect retinal development in eye disc (C) and adult eye (E). Misexpression of arm by ey-GAL4 (ey>arm) caused eye size reduction in adult eye (F) and in eye disc (J). Reduction of omb genetic dosage (l(1)ombD4/+) in the background of ey>arm partially rescued the eye size with full penetrance in adult (G-I) and in eye disc (K, L). 31% of these eye discs showed ventral expansion of retinal differentiation. Interestingly, 44~50% of l(1)ombD4/+; ey>arm flies have dorsal ectopic eyes in adult (I) and in eye discs (6L).