Optomotor-Blind Negatively Regulates Drosophila Eye Development by Blocking Jak/STAT Signaling
Fig 5
omb can repress upd transcription.
(A-A”’) omb expression clone induced by Act5C-GAL4 suppressed upd-lacZ expression (Act5C>omb+GFP in upd-lacZ). (A’-A”’) are a higher magnification of the area marked in (A). GFP (green) marks the Omb expressing cells. Omb expressing cells suppressed upd-lacZ (red). (B-C) RNA in situ hybridization of third instar eye discs. (B) In late third instar, no signal was detected by upd anti-sense probe in wild type eye disc. (C) upd mRNA was ectopically expressed in the ventral eye margin of ombP7/Y. (D, E) Coexpression of omb with upd (in dpp>omb+upd) partially or fully rescued retinal development in the eye disc (D) and adult eye (E). (Elav, red; Wg, blue)