A Mouse Model of L-2-Hydroxyglutaric Aciduria, a Disorder of Metabolite Repair
Fig 9
The average escape latencies, (i.e., the time required for l2hgdh+/+ and l2hgdh-/- mice to reach the platform) on the training day and on the 3 consecutive trial days are shown in (A). The percentage of the time the mice spent in each quadrant of the platform arena on the 5th day of testing (once the platform is removed) is shown in (B). The average distance (in cm) between the position of the mice during the latter test and the position where the platform had been previously placed (Gallagher's coefficient) is shown in (C). Values are expressed as the means ± SEM (n = 9). Statistical analyses were performed using a two-way repeated measures ANOVA (A), a one-way ANOVA (B) followed by a Newman-Keuls test, or a Student t-test (C). *: p < 0.05.