Dystrophic Spinal Deformities in a Neurofibromatosis Type 1 Murine Model
Fig 5
Interarticular fusion in Nf1flox/−;Col2.3Cre mice.
(A) Representative μCT reconstructions of dystrophic vertebral segments in coronal (top, i and ii) or sagittal (bottom, iii and iv) cross-section. Dysplastic bone growth within the intervertebral disc space has led to interarticular fusion of the dystrophic vertebrae. (B) Representative H&E stained histological sections characterize progressive boney dysplasia within the intervertebral disc space of mice at one month (i and ii), two months (iii and iv), six months (v and vi), and 12 months (vii and viii) of age.