Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy
Fig 4
Incidence of early TCMR is higher within young T-cell alloreactive transplant recipients than in elderly patients.
Pre-transplant T-cell alloreactive individuals younger than 50 years old (R<50/ELISPOT+) showed significantly higher incidence of early TCMR than young patients with a negative T-cell ELISPOT (R<50/ELISPOT-) and elderly patients with either a positive (R>50/ELISPOT+) or negative pre-transplant ELISPOT (R>50/ELISPOT-), (6/15;40%, 3/15;20%, 4/15;26.7%, 2/15;13.3%, respectively, p = 0.030). Statistically significant differences were found between alloreactive individuals below 50 (R<50/ELISPOT+) and non-alloreactive patients pre-transplantation [(R<50/ELISPOT-) and (R>50/ELISPOT-)] (p = 0.012 and p = 0.014 respectively). A trend toward a significant difference was observed between patients under 50 and elderly alloreactive patients (p = 0.091).