Development of a Novel Shock Wave Catheter Ablation System -The First Feasibility Study in Pigs-
Fig 4
Time-course of Histopathological Findings of Epicardial Lesions.
The SW-induced lesion at Day 1 (A, E, I, and M), Day 2 (B, F, J, and N), and Day 7 (C, G, K, and O) showed the sphenoidal lesions in each phase. The magnified images at the SW focus site showed the infiltration of inflammatory cells around the degenerated myocardium at Day 1 (E) and more at Day 2 (F). The SW-induced lesion showed homogeneous fibrotic changes at Day 7 (K and O). The RF lesion showed central residual necrotic tissue (D) and a border zone with fibrosis (L and P) and chronic infiltration of inflammatory cells (H) at Day 7. The specimens were stained with hematoxylin—eosin (HE) (A–H) and Masson’s trichrome (MT) (I–P). Scale bars: 1.0 mm (A–D and I–L), and 50 μm (E–H and M–P).