The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium
Fig 3
A) Lack of Ca2+ sensitization by OR-1896.
The effect of EMD57033 (EMD, 3 μM, n = 7) or OR-1896 (1 μM, n = 7)) on the Ca2+ concentration-response relationship. Basal force values (mN): Ctr: 2.5±0.3 vs. OR-1896: 2.4±0.3. Mean ± SEM, * p<0.05. B) PDE3 inhibition by OR-1896. Effect of OR-1896 (1 μM) and PDE inhibitors (Cilostamide, Cil 1 μM; Rolipram, Rol 10 μM) upon PDE activity in homogenates of normal rat heart ventricle. Mean ± SEM, *** = p<0.005, ns = non-significant.