A Chemical Proteomics Approach for the Search of Pharmacological Targets of the Antimalarial Clinical Candidate Albitiazolium in Plasmodium falciparum Using Photocrosslinking and Click Chemistry
Figure 2
In vitro antimalarial activity of albitiazolium and related bifunctional analogs.
The compounds were added at various concentrations to the 3D7 P. falciparum strain and incubated for 48 h. [3H]hypoxanthine was added at 48 h to monitor parasite viability. Parasitemia is expressed as a percentage of the control cultures without drug. Half maximal inhibitory concentrations (IC50) are the concentrations needed to inhibit P. falciparum growth by 50%. The results are expressed as means ± SEM of three independent experiments conducted in triplicate. Albitiazolium (□), UA1936 (◊) and UA2050 (○).