Synthesis and Functional Characterization of Substituted Isoquinolinones as MT2-Selective Melatoninergic Ligands
Figure 3
Competitive receptor binding curves of selective isoquinolinone derivatives.
Intact CHO cells expressing MT1 or MT2 were incubated with [3H]melatonin with or without different concentrations of selected tested compounds or unlabeled melatonin. Data represented mean ± SEM of at least 3 different trials performed in duplicates, and normalized to the maximal binding values (in the absence of tested compound). Estimation of maximal displacement and IC50 and Ki were shown in Table 1.