Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
Figure 5
Effect of BAY 85-3934 administration on peptidoglycan-polysaccharide (PG-PS)-induced inflammatory anemia in female Lewis rats.
Data are presented as means ± SEM. (A) Packed cell volume (PCV) in PG-PS-treated animals administered BAY 85-3934 or vehicle (n = 11–12 animals per group), compared with control animals treated with vehicle alone (n = 5 animals). (B) Relative expression of erythropoietin (EPO) and monocyte chemotactic protein-1 (MCP-1) mRNA in kidney, and hepcidin mRNA in liver at the end of the study. *p<0.05, **p<0.01, and ***p<0.001; t-test.