Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science
Figure 4
Re-evaluating the route to the 2° amine core 3 (blue).
(A) The attempted route based on the patent literature procedure [12]. The dotted lines represent the additional step (red) required to attempt cyclisation strictly under the patent conditions. (B) The revised strategy: cyclise to give 6 followed by debenzylation to give the 2° amine 3 (blue).