Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science
Figure 3
Synthesis of the core 70 was attempted using conditions adapted from the literature [12].
(A) N -Debenzylation of 4 was achieved under palladium-catalysed transfer hydrogenation conditions [17]. (B) Reaction of the ketone 5 with thiopheneethanol 1 in the presence of strong Brønsted acids did not produce the expected spirocycle 3.